This Funding Opportunity Announcement (FOA) encourages transdisciplinary and translational research that will identify specific biological or biobehavioral pathways through which physical activity and/or weight control (either weight loss or avoidance of weight gain) may affect cancer prognosis and survival. Research applications must test the effects of physical activity or weight control or both interventions on biomarkers of cancer prognosis among cancer survivors identified by previous animal or observational research, which may include but are not limited to intervention-induced changes in sex hormones, insulin or insulin-like growth factors or their binding proteins, insulin resistance, glucose metabolism, leptin and other adipokines, immunologic or inflammatory factors, oxidative stress and DNA damage or repair capacity, angiogenesis, or prostaglandins. This research will require transdisciplinary approaches that bring together behavioral intervention expertise, cancer biology, and other basic and clinical science disciplines relevant to the pathways being studied. Understanding the pathways through which these interventions are effective would identify the optimal type and intensity of intervention and determine who is most likely to benefit from these interventions by cancer type, age, or other host factors.
Standard Dates Apply (Expires September 2015)Share via these networks: